2. Academic Validation
  3. Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel

Synthesis and biological evaluation of novel 3'-N-tert-butylsulfonyl analogues of docetaxel

  • Bioorg Med Chem Lett. 2008 Sep 1;18(17):4783-5. doi: 10.1016/j.bmcl.2008.07.101.
Bowen Ke 1,  Yong Qin,  Fengyan Zhao,  Yi Qu
Affiliations

Affiliation

  • 1 Department of Chemistry of Medicinal Natural Products, Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China.
PMID: 18701281 DOI: 10.1016/j.bmcl.2008.07.101
Abstract

Novel 3'-N-tert-butylsulfonyl analogues 10a-c of docetaxel were synthesized and their biological evaluation in cytotoxicity in vitro against several human tumor cell lines were presented. The biologically tested results showed that N-oxide pyridyl substituted10b-c had potent cytotoxicities against human tumor cell lines Eca-109, SKOV3, SMMC-7721, HCT-8, PC3, MCF-7, HeLa and KB.

Figures