2. Academic Validation
  3. Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp

Bioactive asterric acid derivatives from the Antarctic ascomycete fungus Geomyces sp

  • J Nat Prod. 2008 Sep;71(9):1643-6. doi: 10.1021/np8003003.
Yan Li 1,  Bingda Sun,  Shuchun Liu,  Lihua Jiang,  Xingzhong Liu,  Hua Zhang,  Yongsheng Che
Affiliations

Affiliation

  • 1 Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
PMID: 18720971 DOI: 10.1021/np8003003
Abstract

Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed Antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against gram-positive and gram-negative bacteria.

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