2. Academic Validation
  3. TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina

TRAIL-enhancing activity of Erythrinan alkaloids from Erythrina velutina

  • Bioorg Med Chem Lett. 2009 Jan 1;19(1):234-6. doi: 10.1016/j.bmcl.2008.10.111.
Masaaki Ozawa 1,  Tadahiro Etoh,  Masahiko Hayashi,  Kanki Komiyama,  Akio Kishida,  Ayumi Ohsaki
Affiliations

Affiliation

  • 1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda, Tokyo, Japan.
PMID: 19026536 DOI: 10.1016/j.bmcl.2008.10.111
Abstract

A new Erythrinan alkaloid (1), erythodine N-oxide, was isolated from the seeds of Erythrina velutina together with seven known Erythrinan Alkaloids (2-7, 9) and an indole alkaloid (8). The structure of new compound (1) was elucidated by spectroscopic methods. Six of the nine compounds showed enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Erysotrine (4) did not show cytotoxic activity by itself, but exhibited significant cytotoxicity when combined with TRAIL.

Figures