2. Academic Validation
  3. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan

In vitro anti-influenza viral activities of constituents from Caesalpinia sappan

  • Planta Med. 2009 Mar;75(4):337-9. doi: 10.1055/s-0028-1112208.
Ai-Lin Liu 1,  Shi-Hui Shu,  Hai-Lin Qin,  Simon Ming Yuen Lee,  Yi-Tao Wang,  Guan-Hua Du
Affiliations

Affiliation

  • 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
PMID: 19148862 DOI: 10.1055/s-0028-1112208
Abstract

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against Influenza Virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.

Figures
Products