2. Academic Validation
  3. Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters

  • Bioorg Med Chem Lett. 2009 Feb 15;19(4):1118-21. doi: 10.1016/j.bmcl.2008.12.108.
Jérémie Doiron 1,  Luc H Boudreau,  Nadia Picot,  Benoît Villebonet,  Marc E Surette,  Mohamed Touaibia
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
PMID: 19152786 DOI: 10.1016/j.bmcl.2008.12.108
Abstract

Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity.

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