2. Academic Validation
  3. Identification of self peptides bound to purified HLA-B27

Identification of self peptides bound to purified HLA-B27

  • Nature. 1991 Sep 26;353(6342):326-9. doi: 10.1038/353326a0.
T S Jardetzky 1,  W S Lane,  R A Robinson,  D R Madden,  D C Wiley
Affiliations

Affiliation

  • 1 Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
PMID: 1922338 DOI: 10.1038/353326a0
Abstract

A pool of endogenous Peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified Peptides provides information on the binding specificity of the HLA-B27 molecule. The Peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self Peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family.

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