2. Academic Validation
  3. Role of specific microRNAs for endothelial function and angiogenesis

Role of specific microRNAs for endothelial function and angiogenesis

  • Biochem Biophys Res Commun. 2009 Sep 4;386(4):549-53. doi: 10.1016/j.bbrc.2009.06.075.
Fusheng Wu 1,  Zeran Yang,  Guohong Li
Affiliations

Affiliation

  • 1 Department of Neurosurgery & Physiology, LSU Health Science Center, Shreveport, LA 71130, USA.
PMID: 19540203 DOI: 10.1016/j.bbrc.2009.06.075
Abstract

Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis.

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