2. Academic Validation
  3. Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia

Tyrosinase-inhibitory constituents from the twigs of Cinnamomum cassia

  • J Nat Prod. 2009 Jun;72(6):1205-8. doi: 10.1021/np900031q.
Tran Minh Ngoc 1,  IkSoo Lee,  Do Thi Ha,  Hongjin Kim,  ByungSun Min,  KiHwan Bae
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea.
PMID: 19555125 DOI: 10.1021/np900031q
Abstract

A methanol extract of the twigs of Cinnamomum Cassia was found to possess inhibitory activity against Tyrosinase. Purification of the MeOH extract afforded four new phenolics, cassiferaldehyde (6), icariside DC (9), cinnacassinol (10), and dihydrocinnacasside (13), together with 10 known compounds (1-5, 7-12, and 14). The structures of the new compounds were determined by spectroscopic data interpretation. Compounds 1-6 and 8-13 showed strong inhibitory activity against Tyrosinase, with IC(50) values ranging from 0.24 to 0.94 mM.

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