2. Academic Validation
  3. In vitro antiviral activity of V-073 against polioviruses

In vitro antiviral activity of V-073 against polioviruses

  • Antimicrob Agents Chemother. 2009 Oct;53(10):4501-3. doi: 10.1128/AAC.00671-09.
M Steven Oberste 1,  Deborah Moore,  Barbara Anderson,  Mark A Pallansch,  Daniel C Pevear,  Marc S Collett
Affiliations

Affiliation

  • 1 Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
PMID: 19635956 DOI: 10.1128/AAC.00671-09
Abstract

V-073, an Enterovirus capsid inhibitor, was evaluated for its spectrum of antipoliovirus activity. V-073 inhibited all 45 polioviruses tested in a virus-induced cytopathic effect protection assay, with 50% effective concentration (EC50) values ranging from 0.003 to 0.126 microM. Ninety percent of the polioviruses tested were inhibited at EC(50)s of < or = 0.076 microM (MIC90 = 32 ng/ml). V-073 is a promising Antiviral candidate for the posteradication management of poliovirus incidents.

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