2. Academic Validation
  3. Triterpenoid saponins from Rubus ellipticus var. obcordatus

Triterpenoid saponins from Rubus ellipticus var. obcordatus

  • J Nat Prod. 2009 Oct;72(10):1755-60. doi: 10.1021/np900237a.
Wei Li 1,  Hongwei Fu,  Hong Bai,  Tatsunori Sasaki,  Hiroyoshi Kato,  Kazuo Koike
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan. [email protected]
PMID: 19795885 DOI: 10.1021/np900237a
Abstract

Ten new triterpenoid saponins (1-10), named rubusides A-J, and 21 known saponins (11-31) were isolated from the roots of Rubus ellipticus var. obcordatus. The structures of 1-10 were established on the basis of spectroscopic analyses, mainly NMR and MS, and chemical degradations. The compounds demonstrated inhibitory activities against alpha-glucosidase with IC50 values in the range 0.65-3.09 mM.

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