2. Academic Validation
  3. 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6935-8. doi: 10.1016/j.bmcl.2009.10.067.
Ronald C Bernotas 1,  Schuyler A Antane,  Steven E Lenicek,  Simon N Haydar,  Albert J Robichaud,  Boyd L Harrison,  Guo Ming Zhang,  Deborah Smith,  Joseph Coupet,  Lee E Schechter
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. [email protected]
PMID: 19884004 DOI: 10.1016/j.bmcl.2009.10.067
Abstract

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.

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