2. Academic Validation
  3. Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues

Absolute structure-cytotoxic activity relationships of steganacin congeners and analogues

  • J Med Chem. 1991 Jan;34(1):54-7. doi: 10.1021/jm00105a009.
K Tomioka 1,  T Ishiguro,  H Mizuguchi,  N Komeshima,  K Koga,  S Tsukagoshi,  T Tsuruo,  T Tashiro,  S Tanida,  T Kishi
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
PMID: 1992152 DOI: 10.1021/jm00105a009
Abstract

The cytotoxic activities of optically pure and racemic steganacin congeners and analogues against KB cells in culture and the inhibitor activity of cilia regeneration in Tetrahymena were studied with regard to absolute and relative configurations. The stereochemical requirements of dibenzocyclooctadiene lignan lactones for activity were clarified.

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