2. Academic Validation
  3. Synthesis, peroxidating ability, and antineoplastic evaluation of 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones

Synthesis, peroxidating ability, and antineoplastic evaluation of 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones

  • J Med Chem. 1991 Feb;34(2):541-6. doi: 10.1021/jm00106a009.
M Dzieduszycka 1,  S Martelli,  J Tarasiuk,  J Paradziej-Lukowicz,  E Borowski
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland.
PMID: 1995874 DOI: 10.1021/jm00106a009
Abstract

A novel group of cytotoxic anthraquinone derivatives, 1-[(aminoalkyl)amino]-4-hydroxy-10-imino-9-anthracenones, has been synthesized. It has been shown that imino analogues of the anthracenediones exhibit diminished ability to generate oxygen radicals. The cytotoxic activity of iminoanthracenones obtained was lower than that of the related quinone carbonyl analogues. One of the obtained imino compounds showed a moderate antileukemic activity in vivo.

Figures