2. Academic Validation
  3. Synthesis and in vivo evaluation of bicyclic gababutins

Synthesis and in vivo evaluation of bicyclic gababutins

  • Bioorg Med Chem Lett. 2010 Jan 15;20(2):461-4. doi: 10.1016/j.bmcl.2009.11.118.
David C Blakemore 1,  Justin S Bryans,  Pauline Carnell,  Christopher L Carr,  Nicola E A Chessum,  Mark J Field,  Natasha Kinsella,  Simon A Osborne,  Andrew N Warren,  Sophie C Williams
Affiliations

Affiliation

  • 1 Sandwich Laboratories, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. [email protected]
PMID: 20005103 DOI: 10.1016/j.bmcl.2009.11.118
Abstract

Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (-)-(11A) and (20A) which both had an excellent level of potency against alpha(2)delta and were profiled in an in vivo model of neuropathic pain.

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