Antioxidant and antiviral activities of silybin fatty acid conjugates

Eur J Med Chem. 2010 Mar;45(3):1059-67. doi: 10.1016/j.ejmech.2009.11.056.

Radek Gazák ¹, Katerina Purchartová, Petr Marhol, Lucie Zivná, Petr Sedmera, Katerina Valentová, Nobuo Kato, Hiroyo Matsumura, Kunihiro Kaihatsu, Vladimír Kren

Affiliations

Affiliation

1 Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-142 20 Prague, Czech Republic.

PMID: 20036447 DOI: 10.1016/j.ejmech.2009.11.056

Abstract

Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety.

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