2. Academic Validation
  3. Regulation of immunity and oncogenesis by the IRF transcription factor family

Regulation of immunity and oncogenesis by the IRF transcription factor family

  • Cancer Immunol Immunother. 2010 Apr;59(4):489-510. doi: 10.1007/s00262-009-0804-6.
David Savitsky 1,  Tomohiko Tamura,  Hideyuki Yanai,  Tadatsugu Taniguchi
Affiliations

Affiliation

  • 1 Department of Immunology, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
PMID: 20049431 DOI: 10.1007/s00262-009-0804-6
Abstract

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.

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