2. Academic Validation
  3. Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors

Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2809-12. doi: 10.1016/j.bmcl.2010.03.059.
Joseph P Sabatucci 1,  Paige E Mahaney,  Jennifer Leiter,  Grace Johnston,  Kevin Burroughs,  Scott Cosmi,  Yingru Zhang,  Douglas Ho,  Darlene C Deecher,  Eugene Trybulski
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. [email protected]
PMID: 20378347 DOI: 10.1016/j.bmcl.2010.03.059
Abstract

A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.

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