2. Academic Validation
  3. Cucurbitane-type triterpenoids from Momordica charantia

Cucurbitane-type triterpenoids from Momordica charantia

  • Planta Med. 2010 Oct;76(15):1758-61. doi: 10.1055/s-0030-1249807.
Jun Ma 1,  Paul Whittaker,  Amy C Keller,  Eugene P Mazzola,  Rahul S Pawar,  Kevin D White,  John H Callahan,  Edward J Kennelly,  Alexander J Krynitsky,  Jeanne I Rader
Affiliations

Affiliation

  • 1 Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, College Park, MD 20740, USA. [email protected]
PMID: 20379957 DOI: 10.1055/s-0030-1249807
Abstract

One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I (3), momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for Insulin secretion activity in an in vitro Insulin secretion assay and displayed moderate activity.

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