2. Academic Validation
  3. Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

  • Planta Med. 2010 Oct;76(15):1691-3. doi: 10.1055/s-0030-1249782.
Sri Fatmawati 1,  Kuniyoshi Shimizu,  Ryuichiro Kondo
Affiliations

Affiliation

  • 1 Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
PMID: 20379959 DOI: 10.1055/s-0030-1249782
Abstract

CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human Aldose Reductase in vitro. From the acidic fraction, potent human Aldose Reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

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