2. Academic Validation
  3. Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs

Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs

  • Bioorg Med Chem Lett. 2010 May 1;20(9):2722-5. doi: 10.1016/j.bmcl.2010.03.078.
William M Robertson 1,  David B Kastrinsky,  Inkyu Hwang,  Dale L Boger
Affiliations

Affiliation

  • 1 Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 20381346 DOI: 10.1016/j.bmcl.2010.03.078
Abstract

The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.

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