2. Academic Validation
  3. Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

  • Bioorg Med Chem Lett. 2010 Jun 15;20(12):3785-7. doi: 10.1016/j.bmcl.2010.04.054.
Ji Sang Hwang 1,  Seon A Lee,  Seong Su Hong,  Xiang Hua Han,  Chul Lee,  Shin Jung Kang,  Dongho Lee,  Youngsoo Kim,  Jin Tae Hong,  Mi Kyeong Lee,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
PMID: 20483604 DOI: 10.1016/j.bmcl.2010.04.054
Abstract

Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC(50) values ranging from 9.6 microM to 35.7 microM.

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