2. Academic Validation
  3. Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

  • Eur J Med Chem. 2010 Sep;45(9):4403-8. doi: 10.1016/j.ejmech.2010.06.029.
Miguel A González 1,  Juan Mancebo-Aracil,  Veronica Tangarife-Castaño,  Lee Agudelo-Goméz,  Bibiana Zapata,  Ana Mesa-Arango,  Liliana Betancur-Galvis
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Universidad de Valencia, Dr Moliner 50, E-46100 Burjassot, Valencia, Spain. [email protected]
PMID: 20619938 DOI: 10.1016/j.ejmech.2010.06.029
Abstract

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and Antiviral activities. Their precursors were similarly evaluated.

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