1. Academic Validation
  2. Antifungal activity of extracts and prenylated coumarins isolated from Baccharis darwinii Hook & Arn. (Asteraceae)

Antifungal activity of extracts and prenylated coumarins isolated from Baccharis darwinii Hook & Arn. (Asteraceae)

  • Molecules. 2010 Jul 13;15(7):4898-907. doi: 10.3390/molecules15074898.
Rita R Kurdelas 1 Beatriz Lima Alejandro Tapia Gabriela Egly Feresin Manuel Gonzalez Sierra María Victoria Rodríguez Susana Zacchino Ricardo D Enriz Monica L Freile
Affiliations

Affiliation

  • 1 Laboratorio de Productos Naturales Patagónicos (LAPRONAP), Facultad de Ciencias Naturales, Universidad Nacional de la Patagonia San Juan Bosco, Km 4, CP 9000, Comodoro Rivadavia, Chubut, Argentina. [email protected]
Abstract

The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5'-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5'-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobialactivity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 microg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 microg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 microg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.

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