2. Academic Validation
  3. Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis

Preliminary studies of 3,4-dichloroaniline amides as antiparasitic agents: structure-activity analysis of a compound library in vitro against Trichomonas vaginalis

  • Bioorg Med Chem Lett. 2010 Sep 1;20(17):5299-301. doi: 10.1016/j.bmcl.2010.06.133.
Padraick J Dornbush 1,  Cynric Cho,  Elizabeth S Chang,  Lu Xu,  Wade A Russu,  Lisa A Wrischnik,  Kirkwood M Land
Affiliations

Affiliation

  • 1 Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, USA.
PMID: 20667728 DOI: 10.1016/j.bmcl.2010.06.133
Abstract

Trichomonas vaginalis, a human-infectious protozoan, can display resistance to treatment by metronidazole. A library of 3,4-dichloroaniline amides based on propanil, an Herbicide, has been synthesized and screened to test susceptibility to these analogs. From this preliminary study, the most effective compound 15, inhibits growth of the organism by 66% and 69% on the two strains tested, T1 and G3, respectively.

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