2. Academic Validation
  3. Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius

Eucophylline, a Tetracyclic Vinylquinoline Alkaloid from Leuconotis eugenifolius

  • J Nat Prod. 2010 Oct 22;73(10):1727-9. doi: 10.1021/np100458b.
Jun Deguchi 1,  Tomokazu Shoji,  Alfarius E Nugroho,  Yusuke Hirasawa,  Takahiro Hosoya,  Osamu Shirota,  Khalijah Awang,  A Hamid A Hadi,  Hiroshi Morita
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
PMID: 20836516 DOI: 10.1021/np100458b
Abstract

Eucophylline (1), a new tetracyclic vinylquinoline alkaloid, was isolated from the bark of Leuconotis eugenifolius together with leucophyllidine (2). The structure and absolute configuration of 1 were elucidated on the basis of 2D NMR correlations and simulated CD analysis. Leucophyllidine (2) showed iNOS inhibitory activity and decreased the iNOS protein expression dose-dependently.

Figures