2. Academic Validation
  3. New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities

New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities

  • Bioorg Med Chem Lett. 2010 Nov 15;20(22):6624-7. doi: 10.1016/j.bmcl.2010.09.031.
Tamara Costas 1,  Pedro Besada,  Alessandro Piras,  Laura Acevedo,  Matilde Yañez,  Francisco Orallo,  Reyes Laguna,  Carmen Terán
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Universidade de Vigo, 36310 Vigo, Spain.
PMID: 20880705 DOI: 10.1016/j.bmcl.2010.09.031
Abstract

New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents. Analysis of biological data revealed the silyl ethers (4a-i) and N,O-dibenzyl derivatives (6g-i) as the most active compounds.

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