2. Academic Validation
  3. Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents

Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents

  • Bioorg Med Chem Lett. 2010 Nov 15;20(22):6542-6. doi: 10.1016/j.bmcl.2010.09.036.
Andrew Scribner 1,  David Houck,  Zhuhui Huang,  Sarah Mosier,  Michael Peel,  Bernard Scorneaux
Affiliations

Affiliation

  • 1 SCYNEXIS, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA. [email protected]
PMID: 20943390 DOI: 10.1016/j.bmcl.2010.09.036
Abstract

An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.

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