2. Academic Validation
  3. Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei

Antitumor agents, 115. Seselidiol, a new cytotoxic polyacetylene from Seseli mairei

  • J Nat Prod. 1990 Jul-Aug;53(4):932-5. doi: 10.1021/np50070a022.
C Q Hu 1,  J J Chang,  K H Lee
Affiliations

Affiliation

  • 1 Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
PMID: 2095375 DOI: 10.1021/np50070a022
Abstract

Seselidiol [1], a new polyacetylene, has been isolated from the roots of Seseli mairei. On the basis of chemical and spectroscopic evidence, its structure has been established as heptadeca-1,8(Z)-diene-4,6-diyne-3,10-diol. Seselidiol and its acetate have been demonstrated to show moderate cytotoxicity against KB, P-388, and L-1210 tumor cells.

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