2. Academic Validation
  3. The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

  • Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061.
David R Cheshire 1,  Anders Åberg,  Gunilla M K Andersson,  Glen Andrews,  Haydn G Beaton,  Timothy N Birkinshaw,  Nigel Boughton-Smith,  Stephen Connolly,  Tony R Cook,  Anne Cooper,  Sally L Cooper,  David Cox,  John Dixon,  Nigel Gensmantel,  Peter J Hamley,  Richard Harrison,  Paul Hartopp,  Helena Käck,  Paul D Leeson,  Timothy Luker,  Antonio Mete,  Ian Millichip,  David J Nicholls,  Austen D Pimm,  Steve A St-Gallay,  Alan V Wallace
Affiliations

Affiliation

  • 1 Department of Chemistry, AstraZeneca Charnwood, Bakewell Road, Loughborough LE11 5RH, United Kingdom. [email protected]
PMID: 21398123 DOI: 10.1016/j.bmcl.2011.02.061
Abstract

By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.

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