2. Academic Validation
  3. Two new diterpenoids and other constituents from Isodon rubescens

Two new diterpenoids and other constituents from Isodon rubescens

  • Fitoterapia. 2011 Jun;82(4):726-30. doi: 10.1016/j.fitote.2011.03.003.
Rui-Jie Xie 1,  Fu-Lin Yan,  Guang-Fan Hai,  Rui-Jie Hou,  Ming-Ming Ding,  Yi-Xiao Bai
Affiliations

Affiliation

  • 1 Pharmacy College, Xinxiang Medical University, Xinxiang 453003, PR China.
PMID: 21406220 DOI: 10.1016/j.fitote.2011.03.003
Abstract

Two new ent-kaurene Diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by various spectroscopic techniques and finally confirmed by single-crystal X-ray diffraction. Compounds 1, 2, 8 and 12 were evaluated for their cytotoxicities against EC-1, U87, A549, MCF-7 and Hela cell lines.

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