2. Academic Validation
  3. The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase

The discovery and structure-activity relationships of pyrano[3,4-b]indole-based inhibitors of hepatitis C virus NS5B polymerase

  • Bioorg Med Chem Lett. 2011 Jun 1;21(11):3227-31. doi: 10.1016/j.bmcl.2011.04.052.
Randy W Jackson 1,  Matthew G LaPorte,  Torsten Herbertz,  Tandy L Draper,  Janet A Gaboury,  Susan R Rippin,  Ravi Patel,  Srinivas K Chunduru,  Christopher A Benetatos,  Dorothy C Young,  Christopher J Burns,  Stephen M Condon
Affiliations

Affiliation

  • 1 VenatoRx Pharmaceuticals Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA. [email protected]
PMID: 21550237 DOI: 10.1016/j.bmcl.2011.04.052
Abstract

We describe the structure-activity relationship of the C7-position of pyrano[3,4-b]indole-based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compounds 13 and 14.

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