2. Academic Validation
  3. A modular approach to trim cellular targets in anticancer drug discovery

A modular approach to trim cellular targets in anticancer drug discovery

  • Bioorg Med Chem Lett. 2011 Nov 15;21(22):6641-5. doi: 10.1016/j.bmcl.2011.09.069.
Carla Ríos-Luci 1,  Raquel Domínguez-Kelly,  Leticia G León,  Elena Díaz-Rodríguez,  Raimundo Freire,  Atanasio Pandiella,  Inga Cikotiene,  José M Padrón
Affiliations

Affiliation

  • 1 BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
PMID: 21986585 DOI: 10.1016/j.bmcl.2011.09.069
Abstract

A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.

Figures