2. Academic Validation
  3. Salmonella spp. survival strategies within the host gastrointestinal tract

Salmonella spp. survival strategies within the host gastrointestinal tract

  • Microbiology (Reading). 2011 Dec;157(Pt 12):3268-3281. doi: 10.1099/mic.0.050351-0.
Avelino Álvarez-Ordóñez 1 2,  Máire Begley 2,  Miguel Prieto 3,  Winy Messens 4,  Mercedes López 3,  Ana Bernardo 3,  Colin Hill 1 2
Affiliations

Affiliations

  • 1 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
  • 2 Department of Microbiology, University College Cork, Cork, Ireland.
  • 3 Department of Food Hygiene and Technology, Veterinary Faculty, University of León, León, Spain.
  • 4 Biological Hazards (BIOHAZ) Unit, European Food Safety Authority (EFSA), Largo N. Palli 5/A, I-43121 Parma, Italy.
PMID: 22016569 DOI: 10.1099/mic.0.050351-0
Abstract

Human salmonellosis infections are usually acquired via the food chain as a result of the ability of Salmonella serovars to colonize and persist within the gastrointestinal tract of their hosts. In addition, after food ingestion and in order to cause foodborne disease in humans, Salmonella must be able to resist several deleterious stress conditions which are part of the host defence against infections. This review gives an overview of the main defensive mechanisms involved in the Salmonella response to the extreme acid conditions of the stomach, and the elevated concentrations of bile salts, osmolytes and commensal Bacterial metabolites, and the low oxygen tension conditions of the mammalian and avian gastrointestinal tracts.

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