2. Academic Validation
  3. Dimeric ent-kaurane diterpenoids from Isodon excisus

Dimeric ent-kaurane diterpenoids from Isodon excisus

  • J Nat Prod. 2011 Nov 28;74(11):2382-7. doi: 10.1021/np200439n.
Seong Su Hong 1,  Seon A Lee,  Chul Lee,  Xiang Hua Han,  Sanggil Choe,  Nahyun Kim,  Dongho Lee,  Chong-Kil Lee,  Youngsoo Kim,  Jin Tae Hong,  Mi Kyeong Lee,  Bang Yeon Hwang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
PMID: 22066578 DOI: 10.1021/np200439n
Abstract

Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus. The structures and relative configurations of these compounds were determined on the basis of spectroscopic data interpretation. Of these, biexcisusins C-E (3-5) are dimeric ent-kaurane Diterpenoids exhibiting an unprecedented linkage through a nine-membered lactone ring between two ent-kaurane subunits. Compounds 1-5 showed no inhibitory effects on the LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells, up to a dose of 50 μM.

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