2. Academic Validation
  3. A new iridoid glycoside from the roots of Dipsacus asper

A new iridoid glycoside from the roots of Dipsacus asper

  • Molecules. 2012 Feb 3;17(2):1419-24. doi: 10.3390/molecules17021419.
De Ji 1,  Chunfeng Zhang,  Jingzhi Li,  Haowei Yang,  Jingyang Shen,  Zhonglin Yang
Affiliations

Affiliation

  • 1 State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China. [email protected].
PMID: 22306831 DOI: 10.3390/molecules17021419
Abstract

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4',4''-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ₂₅₋₃₅ induced cell death in PC12 cells.

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