2. Academic Validation
  3. 2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7

2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7

  • Chem Biodivers. 2012 Feb;9(2):385-93. doi: 10.1002/cbdv.201100061.
Yu Wang 1,  Zhan-Lin Li,  Jiao Bai,  Li-Min Zhang,  Xin Wu,  Lin Zhang,  Yue-Hu Pei,  Yong-Kui Jing,  Hui-Ming Hua
Affiliations

Affiliation

  • 1 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
PMID: 22344914 DOI: 10.1002/cbdv.201100061
Abstract

Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 6-14. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate Cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC(50) values of 1.8, 0.2, and 0.5 μM, respectively.

Figures
Products