2. Academic Validation
  3. Regulation of TGF-β receptor activity

Regulation of TGF-β receptor activity

  • Cell Biosci. 2012 Mar 15:2:9. doi: 10.1186/2045-3701-2-9.
Fei Huang 1,  Ye-Guang Chen
Affiliations

Affiliation

  • 1 The State Key Laboratory of Biomembrane and Membrane Biotechnology, THU-PKU Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. [email protected].
PMID: 22420375 DOI: 10.1186/2045-3701-2-9
Abstract

TGF-β signaling regulates diverse cellular processes, including cell proliferation, differentiation, Apoptosis, cell plasticity and migration. Its dysfunctions can result in various kinds of diseases, such as Cancer and tissue fibrosis. TGF-β signaling is tightly regulated at different levels along the pathway, and modulation of TGF-β Receptor activity is a critical step for signaling regulation. This review focuses on our recent understanding of regulation of TGF-β Receptor activity.

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