2. Academic Validation
  3. Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS

Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS

  • J Nat Prod. 2012 Jul 27;75(7):1409-13. doi: 10.1021/np300109s.
Yin-He Yang 1,  Xiao-Li Fu,  Liang-Qun Li,  Ying Zeng,  Cheng-Yun Li,  Yi-Neng He,  Pei-Ji Zhao
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
PMID: 22742732 DOI: 10.1021/np300109s
Abstract

Previous analyses of the naphthomycin biosynthetic gene cluster and a comparison with known naphthomycin-type products from Streptomyces sp. CS have suggested that new products can be found from this strain. In this study, screening by LC-MS of Streptomyces sp. CS products formed under different culture conditions revealed several unknown peaks in the product spectra of extracts derived from oatmeal medium cultures. Three new naphthomycins, naphthomycins L (1), M (2), and N (3), and the known naphthomycins A (4), E (5), and D (6) were obtained. The structures were elucidated using spectroscopic data from 1D and 2D NMR and HRESIMS experiments.

Figures