2. Academic Validation
  3. Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling

Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling

  • Eur J Med Chem. 2012 Sep:55:346-57. doi: 10.1016/j.ejmech.2012.07.039.
Yinglin Zuo 1,  Jianing Huang,  Binhua Zhou,  Shuni Wang,  Weiyan Shao,  Cuige Zhu,  Li Lin,  Gesi Wen,  Hongyang Wang,  Jun Du,  Xianzhang Bu
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, PR China.
PMID: 22889562 DOI: 10.1016/j.ejmech.2012.07.039
Abstract

A series of new 4-arylidene curcumin analogues (4-arylidene-1,7-bisarylhepta-1,6-diene-3,5-diones) were synthesized and found to be potent antiproliferative agents against a panel of Cancer cell lines at submicromolar to low micromolar concentrations by SRB assay. Their inhibitory abilities against NF-κB was evaluated by High Content Analysis (HCA) based immunofluorescence assay; and the Akt signalling inhibition was determined by fluorescence polarization assay and western blot respectively. The Structure-Activity Relationship was discussed. Our results revealed that 4-arylidene curcumin analogues may work in a multi-targets manner in Cancer cell.

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