2. Academic Validation
  3. Anthraquinones from a marine-derived Streptomyces spinoverrucosus

Anthraquinones from a marine-derived Streptomyces spinoverrucosus

  • J Nat Prod. 2012 Oct 26;75(10):1759-64. doi: 10.1021/np3004326.
Youcai Hu 1,  Elisabeth D Martinez,  John B MacMillan
Affiliations

Affiliation

  • 1 Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.
PMID: 23057874 DOI: 10.1021/np3004326
Abstract

Four new anthraquinone analogues including galvaquinones A-C (1-3) and an isolation artifact, 5,8-dihydroxy-2,2,4-trimethyl-6-(3-methylbutyl)anthra[9,1-de][1,3]oxazin-7(2H)-one (4), were isolated from a marine-derived Streptomyces spinoverrucosus based on activity in an image-based assay to identify epigenetic modifying compounds. The structures of 1-4 were elucidated by comprehensive NMR and MS spectroscopic analysis. Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 μM and exhibited moderate cytotoxicity against non-small-cell lung Cancer (NSCLC) cell lines Calu-3 and H2887.

Figures