2. Academic Validation
  3. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

  • Phytochemistry. 2013 Feb:86:208-17. doi: 10.1016/j.phytochem.2012.09.003.
Milka Jadranin 1,  Milica Pešić,  Ivana S Aljančić,  Slobodan M Milosavljević,  Nina M Todorović,  Ana Podolski-Renić,  Jasna Banković,  Nikola Tanić,  Ivanka Marković,  Vlatka E Vajs,  Vele V Tešević
Affiliations

Affiliation

  • 1 Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Belgrade, Serbia.
PMID: 23079764 DOI: 10.1016/j.phytochem.2012.09.003
Abstract

Thirteen jatrophane Diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

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