2. Academic Validation
  3. Antiproliferative withanolides from Datura wrightii

Antiproliferative withanolides from Datura wrightii

  • J Nat Prod. 2013 Mar 22;76(3):445-9. doi: 10.1021/np300766p.
Huaping Zhang 1,  Joseph Bazzill,  Robert J Gallagher,  Chitra Subramanian,  Patrick T Grogan,  Victor W Day,  Kelly Kindscher,  Mark S Cohen,  Barbara N Timmermann
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66045, USA.
PMID: 23252848 DOI: 10.1021/np300766p
Abstract

A new withanolide, named withawrightolide (1), and four known withanolides (2-5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and Other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1-5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 μM.

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