2. Academic Validation
  3. Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling

Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling

  • J Biol Chem. 2013 Mar 15;288(11):7430-7437. doi: 10.1074/jbc.R112.444158.
Hsueh-Liang Fu 1,  Rajeshwari R Valiathan 1,  Richard Arkwright 1,  Anjum Sohail 1,  Cosmin Mihai 2,  Malika Kumarasiri 3,  Kiran V Mahasenan 3,  Shahriar Mobashery 3,  Paul Huang 4,  Gunjan Agarwal 2,  Rafael Fridman 5
Affiliations

Affiliations

  • 1 Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201.
  • 2 Davis Heart and Lung Research Institute and Biomedical Engineering Department, Ohio State University, Columbus, Ohio 43210.
  • 3 Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556.
  • 4 Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom.
  • 5 Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201. Electronic address: [email protected].
PMID: 23335507 DOI: 10.1074/jbc.R112.444158
Abstract

The discoidin domain receptors (DDRs) are Receptor Tyrosine Kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from Other members of the kinase superfamily. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of Collagen matrices and potential novel therapeutic targets. New structural and biological information has shed light on the molecular mechanisms that regulate DDR signaling, turnover, and function. This minireview provides an overview of these areas of DDR research with the goal of fostering further investigation of these intriguing and unique receptors.

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