2. Academic Validation
  3. The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes

The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes

  • Autophagy. 2013 Jul;9(7):1097-9. doi: 10.4161/auto.24634.
Wibke Bechtel 1,  Martin Helmstädter,  Jan Balica,  Björn Hartleben,  Christoph Schell,  Tobias B Huber
Affiliations

Affiliation

  • 1 Renal Division; University Hospital Freiburg; Freiburg, Germany.
PMID: 23614954 DOI: 10.4161/auto.24634
Abstract

Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/Vps34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.

Keywords

Pik3c3; Vps34; autophago-lysosomal formation; autophagy; endocytosis; glomerulosclerosis; phosphoinositide 3-kinase; podocyte; proteinuria.

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