2. Academic Validation
  3. Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

  • Cell Immunol. 2013 Jul-Aug;284(1-2):75-83. doi: 10.1016/j.cellimm.2013.07.008.
Yan-Ying Zhao 1,  Dong-Jing Yan,  Zheng-Wang Chen
Affiliations

Affiliation

  • 1 College of Life Science and Technology, Southwest University for Nationalities, Chengdu 610041, China. Electronic address: [email protected].
PMID: 23948156 DOI: 10.1016/j.cellimm.2013.07.008
Abstract

Allograft Inflammatory Factor-1 (AIF-1) is a 17kDa cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 influences the immune system at several key points and thus modulates inflammatory diseases. AIF-1 boosts the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase (iNOS) and promotes inflammatory cell proliferation and migration. Here we provide an overview of the different pathological processes regulated by AIF-1 mainly including allograft rejection, autoimmune diseases, central nervous system (CNS) injury, vasculopathy and Cancer et al.

Keywords

AIF-1; Disease processes; Inflammation; Migration; Proliferation.

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