2. Academic Validation
  3. Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes

Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes

  • Epigenetics. 2014 Feb;9(2):186-93. doi: 10.4161/epi.26792.
Brianna J Klein 1,  Marie-Eve Lalonde 2,  Jacques Côté 2,  Xiang-Jiao Yang 3,  Tatiana G Kutateladze 1
Affiliations

Affiliations

  • 1 Department of Pharmacology; University of Colorado School of Medicine; Aurora, CO USA.
  • 2 Laval University Cancer Research Center; Hôtel-Dieu de Québec (CHUQ); Quebec City, QC Canada.
  • 3 Rosalind and Morris Goodman Cancer Research Center; Departments of Medicine, Biochemistry, and Anatomy & Cell Biology; McGill University; Montréal, QC Canada.
PMID: 24169304 DOI: 10.4161/epi.26792
Abstract

The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.

Keywords

BRPF; ING5; KAT6A; KAT6B; MORF; MOZ; PHD; acetylation; histone; reader.

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