2. Academic Validation
  3. Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L

Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L

  • Plant Cell Rep. 1982 Jun;1(4):168-71. doi: 10.1007/BF00269190.
A Baumert 1,  I N Kuzovkina,  G Krauss,  M Hieke,  D Gröger
Affiliations

Affiliation

  • 1 Institut für Biochemie der Pflanzen, Akademie der Wissenschaften der DDR, DDR-4010 Halle (Saale), Weinberg 3, GDR.
PMID: 24259136 DOI: 10.1007/BF00269190
Abstract

The dihydrofuroacridone, rutacridone, is the main alkaloid in tissue cultures of Ruta graveolens L. strain R-19. The biosynthesis of this particular acridone alkaloid was investigated by using calluses and suspension cultures of strain R-19. Anthranilic acid is specifically incorporated into ring A of rutacridone. Some further evidence was provided that acetate via a polyketide is involved in acridone biosynthesis. Mevalonic acid gave a poor incorporation into rutacridone. Thus the origin of the isopropyldihydrofuran moiety of the investigated alkaloid is still obscure.

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