2. Academic Validation
  3. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines

Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines

  • Phytochemistry. 2014 Feb:98:190-6. doi: 10.1016/j.phytochem.2013.11.025.
Ivana S Aljančić 1,  Ivan Vučković 2,  Milka Jadranin 3,  Milica Pešić 4,  Iris Dorđević 5,  Ana Podolski-Renić 4,  Sonja Stojković 4,  Nebojša Menković 6,  Vlatka E Vajs 7,  Slobodan M Milosavljević 2
Affiliations

Affiliations

  • 1 Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia. Electronic address: [email protected].
  • 2 Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11158 Belgrade, Serbia.
  • 3 Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia.
  • 4 Institute for Biological Research, Department of Neurobiology, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
  • 5 Faculty for Veterinary Medicine, University of Belgrade, Bulevar Oslobodenja 18, 11000 Belgrade, Serbia.
  • 6 Institute for Medicinal Plant Research, "Dr. Josif Pančić", Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
  • 7 Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia; Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11158 Belgrade, Serbia.
PMID: 24361288 DOI: 10.1016/j.phytochem.2013.11.025
Abstract

Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Černjavski & Soška. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo IIα and HIF-1α expression and stimulated doxorubicin Anticancer effect, while 2 increased the expression of HIF-1α, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway.

Keywords

Asteraceae; Chalcone glucoside dimers; Drug combination; Flavonoid glucoside; HIF-1α; Helichrysum zivojinii; MAP kinase pathway; Topoisomerase IIα.

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