2. Academic Validation
  3. Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway

Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway

  • Mol Med. 2014 Mar 13;20(1):17-28. doi: 10.2119/molmed.2013.00102.
Zhenwei Zhang 1,  Lei Miao 2,  Xiaoming Xin 3,  Jianpeng Zhang 4,  Shengsheng Yang 4,  Mingyong Miao 4,  Xiangping Kong 5,  Binghua Jiao 4
Affiliations

Affiliations

  • 1 Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.
  • 2 Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China.
  • 3 Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China Department of Pharmacology, Taishan Medical University, Shandong Province, China.
  • 4 Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.
  • 5 Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.
PMID: 24395568 DOI: 10.2119/molmed.2013.00102
Abstract

Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric Cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell Apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric Cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.

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