2. Academic Validation
  3. Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin

Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin

  • Bioorg Med Chem Lett. 2014 Apr 1;24(7):1724-9. doi: 10.1016/j.bmcl.2014.02.042.
Michał Antoszczak 1,  Ewa Maj 2,  Joanna Stefańska 3,  Joanna Wietrzyk 2,  Jan Janczak 4,  Bogumil Brzezinski 1,  Adam Huczyński 5
Affiliations

Affiliations

  • 1 Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland.
  • 2 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wrocław, Poland.
  • 3 Medical University of Warsaw, Department of Pharmaceutical Microbiology, Oczki 3, 02-007 Warsaw, Poland.
  • 4 Institute of Low Temperature and Structure Research, Polish Academy of Sciences, PO Box 1410, 50-950 Wrocław, Poland.
  • 5 Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland. Electronic address: [email protected].
PMID: 24631190 DOI: 10.1016/j.bmcl.2014.02.042
Abstract

A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human Cancer cell lines including the drug-resistant Cancer cells. Four new salinomycin derivatives revealed good Antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE).

Keywords

Amides; Antibacterial activity; Anticancer properties; Natural compounds; Polyether ionophores.

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